Immunological surveillance and neoplastic development
نویسندگان
چکیده
منابع مشابه
Neoplastic development ie B-Iymplhocytes
Neoplastic transformation is a complex process that results from multiple changes in gene activities. Probably most of these are mutational, i.e. alterations in the genomic structure of DNA, but others may be due to adaptive changes wherein genes are expressed that are inappropriate to a stage of development or differentiation. In this commentary neoplastic development is discussed in the conte...
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The innate and the adaptive immune systems work in concert to deal with pathologies introduced by internal and external factors (e.g., viruses, bacteria, and fungi) – some of which may be associated with the development of autoimmune and cancerous cells. Mechanistically, there are internal factors that are responsible for the hypo-and hyperfunction of immune tolerance apparatus. Consequently, i...
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Inspired by the human immune system, and in particular the negative selection algorithm, we propose a learning mechanism that enables the detection of abnormal activities. Three detectors for detecting abnormal activity are generated using negative selection. Tracks gathered by people’s movements in a room are used for experimentation and results have shown that the classifier is able to discri...
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The detailed analysis of mammary neoplasia in inbred mice has disclosed 3 important etiologic factors, compris ing, as stated in Bittner's 3-factor hypothesis, a genetic factor, a hormonal factor, and a milk-borne tumor agent with the properties of a virus and now usually called the milk agent or the Bittner virus. Within certain limits, an excess of one factor can compensate for deficiency in ...
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Nonviral gene transfer is markedly enhanced by the application of in vivo electroporation (also denoted electro-gene transfer or electrokinetic enhancement). This approach is safe and can be used to deliver nucleic acid fragments, oligonucleotides, siRNA, and plasmids to a wide variety of tissues, such as skeletal muscle, skin and liver. In this review, we address the principles of electroporat...
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ژورنال
عنوان ژورنال: Rocky Mountain Journal of Mathematics
سال: 1979
ISSN: 0035-7596
DOI: 10.1216/rmj-1979-9-1-143